The cellular biology of the Reed-Sternberg cell.
نویسندگان
چکیده
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منابع مشابه
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1Institute of Cell Biology (Cancer Research), University of Duisburg-Essen Medical School, Essen, Germany; 2Institute for Pathology, University of Frankfurt Medical School, Frankfurt, Germany; 3Institute for Informatics, University of Frankfurt, Frankfurt, Germany; 4Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; 5Institute for Pathology, U...
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The malignant Reed-Sternberg cell of Hodgkin's disease, first described a century ago, has resisted in-depth analysis due to its extreme rarity in lymphomatous tissue. To directly study its genome-wide gene expression, approximately 11,000,000 bases (27,518 cDNA sequences) of expressed gene sequence was determined from living single Reed-Sternberg cells, Hodgkin's tissue, and cell lines. This a...
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Although Hodgkin's disease is highly responsive to treatments that cause apoptosis, it remains resistant to the physiological mechanisms intended to cause cell death. Presumably, the Reed-Sternberg cell defies endogenous apoptosis, persists, accumulates, and manifests the malignant disorder seen clinically. The Reed-Sternberg cell expresses several members of the tumor necrosis factor receptor ...
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ورودعنوان ژورنال:
- Blood
دوره 84 4 شماره
صفحات -
تاریخ انتشار 1994